The Reds completely capitulated in the first leg of their quarter-final tie against Atalanta, being thumped at Anfield to leave them with a mountain to climb.
Jurgen Klopp’s side then followed that result up with another shock home defeat to Crystal Palace in the Premier League at the weekend.
They are seemingly now in disarray, but completing a historic European comeback would be the perfect way to turn things around.
Klopp’s final Liverpool farewell wasn’t meant to go like this…
It seemed his side were on their way to a Premier League and Europa League double, with the Reds dominating both competitions.
However, the last week has done some major damage to their trophy chances.
The German said he ‘had nothing positive to say’ after the first leg loss and it’s likely his thoughts were the same following the Palace defeat.
To stay in Europe, Liverpool must make history to become the first-ever team in the competition to overturn a three-goal deficit in the second leg.
So that leaves them in desperate need of a miracle to put an end to what has been a nightmare week for the club.
Martin de Roon will return for Atalanta after he missed his side’s Serie A clash at the weekend due to suspension.
However, Georgio Scalvini and former Arsenal defender Sead Kolasinac are both expected to miss out with injuries.
As for Liverpool, Conor Bradley picked up a knock against Crystal Palace last time out.
He could miss out but the Reds will be boosted by the return of Trent Alexander-Arnold.
Alisson, Diogo Jota and Stefan Bajcetic are all also back while Joel Matip, Ben Doak and Thiago remain sidelined.
Klopp has called for a reaction from his side after the heavy first-leg defeat and the loss to Crystal Palace that followed.
Speaking on Sunday, he said: “The answer is pretty easy. If we play like we did in the first half, how should we win the league?
“If we play like we did in the second half, we can win football games.
“If we can win football games, we will see how many we can win and then we want to be around when the other guys struggle, if they struggle.
“We have to win games anyway. We now have a string of four away games. That would have been tough anyway and it will be tough. We have to deal with that.
“The criticism in these moments is completely fine, it is absolutely right. It is all about how we deal with it.”
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